The Effects of Azathioprine (Imuran) on Purine Synthesis in Clinical Disorders of Purine Metabolism*
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چکیده
منابع مشابه
The effects of azathioprine (imuran) on purine synthesis in clinical disorders of purine metabolism.
Azathioprine, a purine analogue, significantly suppressed the purine synthesis de novo of two gouty patients manifesting overproduction of uric acid, as well as three of four gouty patients who showed normal uric acid production. This suppression is taken as evidence that phosphoribosyl-pyrophosphate amidotransferase, the rate-controlling step in purine synthesis de novo, has a normal sensitivi...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1967
ISSN: 0021-9738
DOI: 10.1172/jci105643